Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.

Citation data:

International journal of molecular sciences, ISSN: 1422-0067, Vol: 16, Issue: 11, Page: 27978-87

Publication Year:
2015
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Repository URL:
https://repository.hkbu.edu.hk/scmd_ja/62
PMID:
26610490
DOI:
10.3390/ijms161126071
PMCID:
PMC4661929
Author(s):
Li, Wan-Fei; Wang, Juan; Zhang, Jing-Jie; Song, Xun; Ku, Chuen-Fai; Zou, Juan; Li, Ji-Xin; Rong, Li-Jun; Pan, Lu-Tai; Zhang, Hong-Jie
Publisher(s):
MDPI AG; MDPI
Tags:
Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science; Anti-HIV activity; Bioactivity evaluation; Ent-kaurane diterpene; Henrin A; Pteris henryi; Medicine and Health Sciences
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article description
Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).