Drunk bugs: Chronic vapour alcohol exposure induces marked changes in the gut microbiome in mice.

Citation data:

Behavioural brain research, ISSN: 1872-7549, Vol: 323, Page: 172-176

Publication Year:
2017
Usage 393
Abstract Views 381
Link-outs 12
Captures 49
Readers 45
Exports-Saves 4
Mentions 1
Comments 1
Social Media 103
Tweets 56
Shares, Likes & Comments 47
Citations 2
Citation Indexes 2
Ratings
Reddit 18
PMID:
28161446
DOI:
10.1016/j.bbr.2017.01.049
Author(s):
Peterson, Veronica L, Jury, Nicholas J, Cabrera-Rubio, Raúl, Draper, Lorraine A, Crispie, Fiona, Cotter, Paul D, Dinan, Timothy G, Holmes, Andrew, Cryan, John F
Publisher(s):
Elsevier BV
Tags:
Neuroscience
Most Recent Tweet View All Tweets
article description
The gut microbiota includes a community of bacteria that play an integral part in host health and biological processes. Pronounced and repeated findings have linked gut microbiome to stress, anxiety, and depression. Currently, however, there remains only a limited set of studies focusing on microbiota change in substance abuse, including alcohol use disorder. To date, no studies have investigated the impact of vapour alcohol administration on the gut microbiome. For research on gut microbiota and addiction to proceed, an understanding of how route of drug administration affects gut microbiota must first be established. Animal models of alcohol abuse have proven valuable for elucidating the biological processes involved in addiction and alcohol-related diseases. This is the first study to investigate the effect of vapour route of ethanol administration on gut microbiota in mice. Adult male C57BL/6J mice were exposed to 4 weeks of chronic intermittent vapourized ethanol (CIE, N=10) or air (Control, N=9). Faecal samples were collected at the end of exposure followed by 16S sequencing and bioinformatic analysis. Robust separation between CIE and Control was seen in the microbiome, as assessed by alpha (p<0.05) and beta (p<0.001) diversity, with a notable decrease in alpha diversity in CIE. These results demonstrate that CIE exposure markedly alters the gut microbiota in mice. Significant increases in genus Alistipes (p<0.001) and significant reductions in genra Clostridium IV and XIVb (p<0.001), Dorea (p<0.01), and Coprococcus (p<0.01) were seen between CIE mice and Control. These findings support the viability of the CIE method for studies investigating the microbiota-gut-brain axis and align with previous research showing similar microbiota alterations in inflammatory states during alcoholic hepatitis and psychological stress.

This article has 0 Wikipedia mention.