Serum sclerostin decreases following 12months of resistance- or jump-training in men with low bone mass.

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Bone, ISSN: 1873-2763, Vol: 96, Page: 85-90

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Hinton, Pamela S; Nigh, Peggy; Thyfault, John
Elsevier BV
Medicine; Biochemistry, Genetics and Molecular Biology
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We previously reported that 12months of resistance training (RT, 2×/wk, N=19) or jump training (JUMP, 3×/wk, N=19) increased whole body and lumbar spine BMD and increased serum bone formation markers relative to resorption in physically active (≥4h/wk) men (mean age: 44±2y; median: 44y) with osteopenia of the hip or spine. The purpose of this secondary analysis was to examine the effects of the RT or JUMP intervention on potential endocrine mediators of the exercise effects on bone, specifically IGF-I, PTH and sclerostin.