Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis.

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Best practice & research. Clinical obstetrics & gynaecology, ISSN: 1532-1932, Vol: 50, Page: 27-38

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Cousins, Fiona L; O, Dorien F; Gargett, Caroline E
Elsevier BV
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Human endometrium regenerates on a cyclical basis each month, likely mediated by endometrial stem/progenitor cells. Several types of stem/progenitor cells have been identified: CD140bCD146 or SUSD2 endometrial mesenchymal stem cells (eMSCs), N-cadherin endometrial epithelial progenitor cells (eEPs), and side population (SP) cells, a heterogeneous population predominantly comprising endothelial cells. eMSCs reside in a perivascular niche and likely mediate angiogenesis and stromal regeneration. Human eEPs are located in the bases of glands in the basalis and are likely more primitive than SSEA-1 basalis epithelial cells. Endometrial stem/progenitor cells may contribute to the pathogenesis of endometriosis by their retrograde shedding into the pelvic cavity, either after menarche or as a result of neonatal uterine bleeding. eMSCs may have a role in the generation of progesterone-resistant phenotype of endometrial stromal fibroblasts (eSFs) in endometriosis. In future clinical practice, endometrial stem/progenitor cells may be used to establish diagnosis of endometriosis or as therapeutic targets.