FOXP3 regulatory T cell ameliorates microvasculature in the rejection of mouse orthotopic tracheal transplants.

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Clinical immunology (Orlando, Fla.), ISSN: 1521-7035, Vol: 174, Page: 84-98

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Khan, Mohammad Afzal; Alanazi, Fatimah; Ahmed, Hala Abdalrahman; Al-Mohanna, Falah Hassan; Assiri, Abdullah Mohammed; Broering, Dieter Clemens
Elsevier BV
Medicine; Immunology and Microbiology
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Microvascular loss may be a root cause of chronic rejection in lung transplants, which leads to the bronchiolitis obliterans syndrome. Previous research implicates T regulatory cell (Treg) as a key component of immune modulation, however, Treg has never been examined as a reparative mediator to salvage microvasculature during transplantation. Here, we reconstituted purified Tregs in to allografts, and serially monitored allografts for tissue oxygenation, microvascular perfusion for four weeks. We demonstrated that Tregs reconstitution of allografts significantly improve tissue oxygenation, microvascular flow, epithelial repair, number of CD4CD25FOXP3 Tregs, followed by an upregulation of proinflammatory, angiogenic and regulatory genes, while prevented subepithelial deposition of CD4T cells at d10, and collagen at d28 post-transplantation. Altogether, these findings concluded that Treg-mediated immunotherapy has potential to preserve microvasculature and rescue allograft from sustained hypoxic/ischemic phase, limits airway tissue remodeling, and therefore may be a useful therapeutic tool to prevent chronic rejection after organ transplantation.