Functional Roles for Exosomal MicroRNAs in the Tumour Microenvironment.

Citation data:

Computational and structural biotechnology journal, ISSN: 2001-0370, Vol: 15, Page: 8-13

Publication Year:
2017
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PMID:
27872688
DOI:
10.1016/j.csbj.2016.10.005
PMCID:
PMC5109280
Author(s):
Bell, Emma, Taylor, Molly A
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology, Computer Science
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review description
Extracellular microRNAs are released from cells both passively and actively. The presence of these microRNAs in the tumour microenvironment (TME) can significantly impact on the plasticity of cancer cells leading to the promotion of metastatic and angiogenic processes. These extracellular microRNAs can act not only on other cancer cells, but also cells present in the TME, such as immune cells, endothelial cells, fibroblasts, and others acting to subvert the host immune system and drive tumour progression. In this review we highlight the current understanding of both the mechanisms by which microRNAs are released from tumour cells and the downstream functional effects that extracellular microRNAs have on recipient cells.

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