Role of red blood cells "annexin V" and platelets "P-selectin" in patients with thalassemia.

Citation data:

Hematology/oncology and stem cell therapy, ISSN: 1658-3876

Publication Year:
2018
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PMID:
30028953
DOI:
10.1016/j.hemonc.2018.07.001
Author(s):
Mahdi, Zahraa Najah; Al-Mudallal, Subh S; Hameed, Bassam M
Publisher(s):
Elsevier BV
Tags:
Medicine
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article description
Certain hemostatic anomalies found in patients with thalassemia suggest the existence of a chronic hypercoagulable state. Several etiologic factors may play a role in the pathogenesis of the hypercoagulable state in those patients. One of these factors is abnormal thalassemic red blood cells (RBCs), which may provide a procoagulant. To substantiate these findings, we measured the ability of RBCs from thalassemia patients to bind annexin V with increased fraction of platelets carrying the activation marker CD62P (P-selectin). To study the expression of RBC annexin V and platelets P-selectin in study patients (those with thalassemia major, thalassemia intermedia, thalassemia minor) and control group, four-color flow cytometry was performed and the correlation between these two markers was evaluated.