Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity, and plasma testosterone levels in hypogonadal men.

Citation data:

Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese, ISSN: 2241-5955, Vol: 59, Issue: 4, Page: 201-206

Publication Year:
2018
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PMID:
29128547
DOI:
10.1016/j.hjc.2017.10.004
Author(s):
Tsikas, Dimitrios; Kinzel, Manfred
Publisher(s):
Elsevier BV
Tags:
Medicine
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article description
Circulating inorganic nitrite (NO) is an abundant nitric oxide (NO) reservoir. Renal carbonic anhydrase (CA) mediates the absorption of urinary nitrite. The urinary nitrate-to-nitrite molar ratio UR is a measure of nitrite-dependent renal CA activity. The CA family is also involved in the bioactivation of nitrite to S-nitrosothiols and NO. Thus, CA isoforms may combat atherosclerosis.