Preterm birth: Inflammation, fetal injury and treatment strategies.

Citation data:

Journal of reproductive immunology, ISSN: 1872-7603, Vol: 119, Page: 62-66

Publication Year:
Usage 71
Abstract Views 49
Link-outs 22
Captures 24
Readers 24
Social Media 15
Tweets 11
Shares, Likes & Comments 4
Citations 8
Citation Indexes 8
Boyle, Ashley K; Rinaldi, Sara F; Norman, Jane E; Stock, Sarah J
Elsevier BV
Medicine; Immunology and Microbiology
Most Recent Tweet View All Tweets
review description
Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain. This review will outline (i) the role of inflammation in term and PTB, (ii) the effect infection/inflammation has on fetal development and (iii) recent strategies to target PTB. Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury.