Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate: An open-label, proof-of-principle pilot trial.

Citation data:

Medical hypotheses, ISSN: 1532-2777, Vol: 114, Page: 45-48

Publication Year:
Captures 11
Readers 11
Mentions 1
Blog Mentions 1
Social Media 396
Shares, Likes & Comments 348
Tweets 48
Citations 1
Citation Indexes 1
Comhaire, Frank
Elsevier BV
Most Recent Tweet View All Tweets
Most Recent Blog Mention
article description
Twenty-two consecutive patients suffering from refractory myalgic encephalitis/chronic fatigue syndrome (ME/CFS) were treated with an innovative nutriceutical containing sodium dichloroacetate in a proof-of-principle, pilot, open-label prospective cohort trial. Ten patients experienced significant improvement of their health condition with reduction to almost half of their score in the fatigue severity scale. In twelve patients treatment failed to exert any beneficial effect. In the latter patients several other diseases have commonly been revealed by extensive biological and imaging investigations. These preliminary findings sustain the hypothetical role of mitochondrial hypo-metabolism due to inhibition of the activity of the pyruvate dehydrogenase in the pathogenesis of primary ME/CFS, and suggest a possible benefit of nutriceutical treatment by sodium dichloroacetate.