γ-Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178.

Citation data:

Phytochemistry, ISSN: 1873-3700, Vol: 137, Page: 165-173

Publication Year:
2017
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PMID:
28228227
DOI:
10.1016/j.phytochem.2017.02.008
Author(s):
Phainuphong, Patima; Rukachaisirikul, Vatcharin; Tadpetch, Kwanruthai; Sukpondma, Yaowapa; Saithong, Saowanit; Phongpaichit, Souwalak; Preedanon, Sita; Sakayaroj, Jariya
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences
article description
Chromatographic separation of the broth extract of the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones A-D, a furanone derivative, aspersclerotiorone E, and two γ-butenolide derivatives, aspersclerotiorones F and G, together with six known compounds, penicillic acid, dihydropenicillic acid, 5,6-dihydro-6-hydroxypenicillic acid, 6-methoxy-5,6-dihydropenicillic acid, coculnol and (4R,5R)-4,5-dihydroxy-3-methoxy-5-methylcyclohex-2-en-1-one. Their structures were determined by spectroscopic evidence. For aspersclerotiorones A and B, the structures were confirmed by single-crystal X-ray diffraction crystallography. Penicillic acid displayed weak antibacterial activity against Staphylococcus aureus and Escherichia coli with equal MIC values of 128 μg/mL, and it was noncytotoxic towards African green monkey kidney fibroblast cells.