Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice.

Citation data:

Reproductive toxicology (Elmsford, N.Y.), ISSN: 1873-1708, Vol: 68, Page: 154-163

Publication Year:
Usage 16
Abstract Views 13
Link-outs 3
Captures 20
Readers 19
Exports-Saves 1
Social Media 51
Shares, Likes & Comments 36
Tweets 15
Citations 13
Citation Indexes 13
Kochmanski, Joseph; Marchlewicz, Elizabeth H; Savidge, Matthew; Montrose, Luke; Faulk, Christopher; Dolinoy, Dana C
Elsevier BV
Pharmacology, Toxicology and Pharmaceutics
Most Recent Tweet View All Tweets
article description
Environmental factors, including exogenous exposures and nutritional status, can affect DNA methylation across the epigenome, but effects of exposures on age-dependent epigenetic drift remain unclear. Here, we tested the hypothesis that early-life exposure to bisphenol A (BPA) and/or variable diet results in altered epigenetic drift, as measured longitudinally via target loci methylation in paired mouse tail tissue (3 wks/10 mos old). Methylation was quantified at two repetitive elements (LINE-1, IAP), two imprinted genes (Igf2, H19), and one non-imprinted gene (Esr1) in isogenic mice developmentally exposed to Control, Control+BPA (50μg/kg diet), Mediterranean, Western, Mediterranean+BPA, or Western+BPA diets. Across age, methylation levels significantly (p<0.050) decreased at LINE-1, IAP, and H19, and increased at Esr1. Igf2 demonstrated Western-specific changes in early-life methylation (p=0.027), and IAP showed marginal negative modification of drift in Western (p=0.058) and Western+BPA (p=0.051). Thus, DNA methylation drifts across age, and developmental nutritional exposures can alter age-related methylation patterns.