Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice.

Citation data:

Reproductive toxicology (Elmsford, N.Y.), ISSN: 1873-1708, Vol: 68, Page: 154-163

Publication Year:
2017
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PMID:
27496716
DOI:
10.1016/j.reprotox.2016.07.021
Author(s):
Kochmanski, Joseph, Marchlewicz, Elizabeth H, Savidge, Matthew, Montrose, Luke, Faulk, Christopher, Dolinoy, Dana C
Publisher(s):
Elsevier BV
Tags:
Pharmacology, Toxicology and Pharmaceutics
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article description
Environmental factors, including exogenous exposures and nutritional status, can affect DNA methylation across the epigenome, but effects of exposures on age-dependent epigenetic drift remain unclear. Here, we tested the hypothesis that early-life exposure to bisphenol A (BPA) and/or variable diet results in altered epigenetic drift, as measured longitudinally via target loci methylation in paired mouse tail tissue (3 wks/10 mos old). Methylation was quantified at two repetitive elements (LINE-1, IAP), two imprinted genes (Igf2, H19), and one non-imprinted gene (Esr1) in isogenic mice developmentally exposed to Control, Control+BPA (50μg/kg diet), Mediterranean, Western, Mediterranean+BPA, or Western+BPA diets. Across age, methylation levels significantly (p<0.050) decreased at LINE-1, IAP, and H19, and increased at Esr1. Igf2 demonstrated Western-specific changes in early-life methylation (p=0.027), and IAP showed marginal negative modification of drift in Western (p=0.058) and Western+BPA (p=0.051). Thus, DNA methylation drifts across age, and developmental nutritional exposures can alter age-related methylation patterns.

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