Diphenyl ethers and indanones from the soil-derived fungus Aspergillus unguis PSU-RSPG204

Citation data:

Tetrahedron, ISSN: 0040-4020, Vol: 73, Issue: 40, Page: 5920-5925

Publication Year:
2017
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DOI:
10.1016/j.tet.2017.08.039
Author(s):
Patima Phainuphong; Vatcharin Rukachaisirikul; Souwalak Phongpaichit; Sita Preedanon; Jariya Sakayaroj
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry
article description
Two new indanones, asperunguisones A-B ( 1 – 2 ), and three new diphenyl ethers, aspergillusethers B-D ( 3 – 5 ), were isolated from the soil-derived fungus Aspergillus unguis PSU-RSPG204 together with five known compounds including methyl orsellinate ( 6 ), pilobolusate ( 7 ), aspergillusphenol A ( 8 ), orcinol ( 9 ) and (+)-montagnitol ( 10 ). Their structures were established by spectroscopic evidence. Compound 8 showed moderate antibacterial activity against Staphylococcus aureus and methicillin-resistance S. aureus with MIC values of 16 and 8  μ g/mL, respectively, whereas compound 5 exhibited moderate antifungal activity against Candida albicans (NCPF3153), flucytosine-resistant Cryptococcus neoformans (ATCC90113) and Penicillium marnefeii with the MIC values of 16, 8 and 16  μ g/mL, respectively. For cytotoxic activity, compound 7 showed strong activity against the human oral carcinoma (KB) cell lines with an IC 50 value of 4.57  μ M. In addition, all of them were inactive against African green monkey kidney fibroblast cells.