Diphenyl ethers and indanones from the soil-derived fungus Aspergillus unguis PSU-RSPG204
- Citation data:
Tetrahedron, ISSN: 0040-4020, Vol: 73, Issue: 40, Page: 5920-5925
- Publication Year:
- Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry
Two new indanones, asperunguisones A-B ( 1 – 2 ), and three new diphenyl ethers, aspergillusethers B-D ( 3 – 5 ), were isolated from the soil-derived fungus Aspergillus unguis PSU-RSPG204 together with five known compounds including methyl orsellinate ( 6 ), pilobolusate ( 7 ), aspergillusphenol A ( 8 ), orcinol ( 9 ) and (+)-montagnitol ( 10 ). Their structures were established by spectroscopic evidence. Compound 8 showed moderate antibacterial activity against Staphylococcus aureus and methicillin-resistance S. aureus with MIC values of 16 and 8 μ g/mL, respectively, whereas compound 5 exhibited moderate antifungal activity against Candida albicans (NCPF3153), flucytosine-resistant Cryptococcus neoformans (ATCC90113) and Penicillium marnefeii with the MIC values of 16, 8 and 16 μ g/mL, respectively. For cytotoxic activity, compound 7 showed strong activity against the human oral carcinoma (KB) cell lines with an IC 50 value of 4.57 μ M. In addition, all of them were inactive against African green monkey kidney fibroblast cells.