Endotoxemia and human liver transplantation

Citation data:

Transplantation Proceedings, ISSN: 0041-1345, Vol: 21, Issue: 5, Page: 3833 - 3841

Publication Year:
1989
Usage 176
Downloads 176
Repository URL:
http://d-scholarship.pitt.edu/id/eprint/4392
Pitt D-Scholarship Id:
4392
Author(s):
I Yokoyama; S Todo; T Miyata; R Selby; AG Tzakis; TE Starzl
article description
Ninety liver transplantations were performed in 81 patients. Plasma endotoxin was measured preoperatively, at the end of the anhepatic phase, and on postoperative days 1, 3, and 7. The presence of high endotoxin levels preoperatively and at the end of the anhepatic period was associated with graft failure and a high mortality. Patients with primary nonfunction of their transplants typically had severe endotoxemia. Endotoxemia could be a cause rather than an effect of perioperative complications and graft loss.