The speed of change: towards a discontinuity theory of immunity?

Citation data:

Nature reviews. Immunology, ISSN: 1474-1741, Vol: 13, Issue: 10, Page: 764-9

Publication Year:
Usage 595
Downloads 329
Clicks 117
Abstract Views 71
Full Text Views 64
Link-outs 14
Captures 2
Exports-Saves 2
Mentions 2
References 2
Social Media 11
Tweets 8
Shares, Likes & Comments 3
Citations 49
Citation Indexes 49
Repository URL:
Pradeu, Thomas, Jaeger, S├ębastien, Vivier, Eric
Springer Nature, Nature Group
Immunology and Microbiology
Most Recent Tweet View All Tweets
review description
Immunology - though deeply experimental in everyday practice - is also a theoretical discipline. Recent advances in the understanding of innate immunity, how it is triggered and how it shares features that have previously been uniquely ascribed to the adaptive immune system, can contribute to the refinement of the theoretical framework of immunology. In particular, natural killer cells and macrophages are activated by transient modifications, but adapt to long-lasting modifications that occur in the surrounding tissue environment. This process facilitates the maintenance of self-tolerance while permitting efficient immune responses. In this Essay we extend this idea to other components of the immune system and we propose some general principles that lay the foundations for a unifying theory of immunity - the discontinuity theory. According to this theoretical framework, effector immune responses (namely, activated responses that lead to the potential elimination of the target antigen) are induced by an antigenic discontinuity; that is, by the sudden modification of molecular motifs with which immune cells interact.

This review has 2 Wikipedia mentions.

Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, an...

Read full Article


Immunology is a branch of biology that covers the study of immune systems in all organisms.Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information The Russian biologist Ilya Ilyich Mechnikov advanced studies on immun...

Read full Article