Dissolving the missing heritability problem

Publication Year:
Usage 261
Downloads 261
Repository URL:
Bourrat, Pierrick; Lu, Qiaoying
conference paper description
Heritability estimates obtained in genome-wide association studies (GWAS) are much lower than those of traditional quantitative methods. This has been called the “missing heritability problem”. By analyzing and comparing these two kinds of methods, we first show that the estimates obtained by traditional methods involve some terms that GWAS do not. Second, the estimates obtained by GWAS do not take into account epigenetic factors transmitted across generations, whilst they are included in the estimates of traditional quantitative methods. Once these two factors are taken into account, we show that the missing heritability problem can be largely dissolved. Finally, we briefly contextualize our analysis within a current discussion on how non-additive factors relate to the heritability estimates in GWAS