Multiple sclerosis : how cognitive performance relates to quality of life, depression, and perception of deficits

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Allen, Rebecca
Oregon Health & Science University
Multiple sclerosis; Quality of life; Cognition disorders; Depression; Multiple Sclerosis; Quality of Life; Cognition Disorders; Conditioning (Psychology)
thesis / dissertation description
Introduction: Cognitive impairment is common in multiple sclerosis (MS). The negative consequences of cognitive impairment on daily activities makes early detection important, but subjective cognitive complaints may be attributed to depression. In this study we sought to add to current understanding of cognitive impairment in MS by examining its relationship to quality of life, depression, self-perception of deficits, and caregiver perception of deficits. We also closely examined the relationship between subjectively reported, caregiver reported, and objectively measured cognitive impairment in MS. Methods: A neuropsychological battery of tests, measures of mental and physical quality of life (the mental [MCS] and physical [PCS] composite scores of the Short Form-36), the Perceived Deficits Questionnaire (PDQ), and the Beck Depression Inventory (BDI) were administered to 119 MS patients participating in a clinical trial. The Multiple Sclerosis Neuropsychological Questionnaire-Informant