Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells.

Citation data:

Cancer chemotherapy and pharmacology, ISSN: 1432-0843, Vol: 68, Issue: 5, Page: 1315-23

Publication Year:
2011
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Repository URL:
https://repository.hkbu.edu.hk/hkbu_staff_publication/1680; http://182.93.39.69:81/irpui/item/ir/5258
PMID:
21461888
DOI:
10.1007/s00280-011-1624-x
Author(s):
Li, Ying-Wei; Zhu, Guo-Yuan; Shen, Xiao-Ling; Chu, Jian-Hong; Yu, Zhi-Ling; Fong, Wang-Fun
Publisher(s):
Springer Nature; Springer Verlag; CANCER CHEMOTHERAPY AND PHARMACOLOGY
Tags:
Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics; Breast cancer; EGFR; Furanodienone; HER2; Journal
article description
Overexpression of EGFR and HER2 is seen in breast cancers and results in poor prognosis and decreased patient survival. Clinically, EGFR and HER2 are effective therapeutic targets. The objective of this study is to investigate the in vitro effects of furanodienone, an active chemical component isolated from Rhizoma Curcumae, on the activation of EGFR/HER2 signaling, cell cycle, and apoptosis in HER2-overexpressing BT474 and SKBR3 cells.