Protein domain recurrence and order can enhance prediction of protein functions.
- Citation data:
Bioinformatics (Oxford, England), ISSN: 1367-4811, Vol: 28, Issue: 18, Page: i444-i450
- Publication Year:
- Repository URL:
- PMC3436825; 3436825
- Biochemistry, Genetics and Molecular Biology; Computer Science; Mathematics; Medicine; protein; Bayes theorem; physiology; protein tertiary structure; sequence analysis; statistical model; Bayes Theorem; Models, Statistical; Protein Structure, Tertiary; Proteins; Sequence Analysis, Protein
Burgeoning sequencing technologies have generated massive amounts of genomic and proteomic data. Annotating the functions of proteins identified in this data has become a big and crucial problem. Various computational methods have been developed to infer the protein functions based on either the sequences or domains of proteins. The existing methods, however, ignore the recurrence and the order of the protein domains in this function inference.