Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server.
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Bioinformatics (Oxford, England), ISSN: 1367-4811, Vol: 29, Issue: 18, Page: 2285-91
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- Biochemistry, Genetics and Molecular Biology; Computer Science; Mathematics; Medicine; Software
Antibodies or immunoglobulins are proteins of paramount importance in the immune system. They are extremely relevant as diagnostic, biotechnological and therapeutic tools. Their modular structure makes it easy to re-engineer them for specific purposes. Short of undergoing a trial and error process, these experiments, as well as others, need to rely on an understanding of the specific determinants of the antibody binding mode.