Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server.

Citation data:

Bioinformatics (Oxford, England), ISSN: 1367-4811, Vol: 29, Issue: 18, Page: 2285-91

Publication Year:
2013
Usage 69
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Citations 22
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Repository URL:
http://hdl.handle.net/10754/596812
PMID:
23803466
DOI:
10.1093/bioinformatics/btt369
PMCID:
PMC3753563
Author(s):
Olimpieri, Pier Paolo; Chailyan, Anna; Tramontano, Anna; Marcatili, Paolo
Publisher(s):
Oxford University Press (OUP)
Tags:
Biochemistry, Genetics and Molecular Biology; Computer Science; Mathematics; Medicine; Software
article description
Antibodies or immunoglobulins are proteins of paramount importance in the immune system. They are extremely relevant as diagnostic, biotechnological and therapeutic tools. Their modular structure makes it easy to re-engineer them for specific purposes. Short of undergoing a trial and error process, these experiments, as well as others, need to rely on an understanding of the specific determinants of the antibody binding mode.