Asymptotic stability of constant steady states for a 2×2 reaction–diffusion system arising in cancer modelling

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Mathematical and Computer Modelling, ISSN: 0895-7177, Vol: 53, Issue: 7, Page: 1457-1468

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Di Francesco, Marco; Twarogowska, Monika
Elsevier BV
Mathematics; Computer Science; Asymptotic stability; Cancer modeling; Chemotaxis; Cross diffusion; Reaction-diffusion systems
article description
The dependence of tumor on essential nutrients is known to be crucial for its evolution and has become one of the targets for medical therapies. Based on this fact a reaction–diffusion system with chemotaxis term and nutrient-based growth of tumors is presented. The formulation of the model considers also an influence of tumor and pharmacological factors on nutrient concentration. In the paper, convergence of solutions to constant, stationary states in the one-dimensional case for small perturbation of the equilibria is investigated. The nonlinear stability results are obtained by means of the classical symmetrization method and energy Sobolev estimates.