A magnetic particle micro-trap for large trapping surfaces

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Procedia Engineering, ISSN: 1877-7058, Vol: 25, Page: 1201-1204

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Gooneratne, Chinthaka P.; Liang, Cai; Giouroudi, Ioanna; Kosel, Jürgen
Elsevier BV
Engineering; magnetic particle; micro-trap; cytometry
article description
Manipulation of micron-size magnetic particles of the superparamagnetic type contributes significantly in many applications like controlling the antibody/antigen binding process in immunoassays. Specifically, more target biomolecules can be attached/tagged and analyzed since the three dimensional structure of the magnetic particles increases the surface to volume ratio. Additionally, such biomolecular-tagged magnetic particles can be easily manipulated by an external magnetic field due to their superparamagnetic behavior. Therefore, magnetic particle- based immunoassays are extensively applied in micro-flow cytometry. The design of a square-loop micro-trap as a magnetic particle manipulator as well as numerical and experimental analysis is presented. Experimental results showed that the micro-trap could successfully trap and concentrate magnetic particles from a large to a small area with a high spatial range.