Genome-wide analysis of regions similar to promoters of histone genes.

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BMC systems biology, ISSN: 1752-0509, Vol: 4 Suppl 1, Issue: Suppl 1, Page: S4

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PMC2880410; 2880410
Chowdhary, Rajesh; Bajic, Vladimir B.; Dong, Difeng; Wong, Limsoon; Liu, Jun S
Springer Nature; BioMed Central
Biochemistry, Genetics and Molecular Biology; Mathematics; Computer Science; histone; Bayes theorem; genetics; genomics; human genome; promoter region; Bayes Theorem; Genome, Human; Genomics; Histones; Promoter Regions, Genetic
article description
The purpose of this study is to: i) develop a computational model of promoters of human histone-encoding genes (shortly histone genes), an important class of genes that participate in various critical cellular processes, ii) use the model so developed to identify regions across the human genome that have similar structure as promoters of histone genes; such regions could represent potential genomic regulatory regions, e.g. promoters, of genes that may be coregulated with histone genes, and iii/ identify in this way genes that have high likelihood of being coregulated with the histone genes.