Genome-wide RIP-Chip analysis of translational repressor-bound mRNAs in the Plasmodium gametocyte.

Citation data:

Genome biology, ISSN: 1474-760X, Vol: 15, Issue: 11, Page: 493

Publication Year:
2014
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Citations 35
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Repository URL:
http://hdl.handle.net/10754/337000
PMID:
25418785
DOI:
10.1186/s13059-014-0493-0
PMCID:
PMC4234863; 4234863
Author(s):
Guerreiro, Ana; Deligianni, Elena; Santos, Jorge M; Silva, Patricia A G C; Louis, Christos; Pain, Arnab; Janse, Chris J; Franke-Fayard, Blandine; Carret, Celine K; Siden-Kiamos, Inga; Mair, Gunnar R Show More Hide
Publisher(s):
Springer Nature; BioMed Central
Tags:
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
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article description
Following fertilization, the early proteomes of metazoans are defined by the translation of stored but repressed transcripts; further embryonic development relies on de novo transcription of the zygotic genome. During sexual development of Plasmodium berghei, a rodent model for human malaria species including P. falciparum, the stability of repressed mRNAs requires the translational repressors DOZI and CITH. When these repressors are absent, Plasmodium zygote development and transmission to the mosquito vector is halted, as hundreds of transcripts become destabilized. However, which mRNAs are direct targets of these RNA binding proteins, and thus subject to translational repression, is unknown.