On the classification of long non-coding RNAs.

Citation data:

RNA biology, ISSN: 1555-8584, Vol: 10, Issue: 6, Page: 925-33

Publication Year:
2013
Usage 10
Abstract Views 9
Link-outs 1
Captures 696
Readers 696
Mentions 2
References 1
Blog Mentions 1
Citations 211
Citation Indexes 211
Repository URL:
http://hdl.handle.net/10754/566007
PMID:
23696037
DOI:
10.4161/rna.24604
PMCID:
PMC4111732
Author(s):
Ma, Lina; Bajic, Vladimir B.; Zhang, Zhang
Publisher(s):
Informa UK Limited; Taylor & Francis
Tags:
Biochemistry, Genetics and Molecular Biology; lncRNA; lncRNA classification; Long non-coding RNA; RNA transcripts
Most Recent Blog Mention
review description
Long non-coding RNAs (lncRNAs) have been found to perform various functions in a wide variety of important biological processes. To make easier interpretation of lncRNA functionality and conduct deep mining on these transcribed sequences, it is convenient to classify lncRNAs into different groups. Here, we summarize classification methods of lncRNAs according to their four major features, namely, genomic location and context, effect exerted on DNA sequences, mechanism of functioning and their targeting mechanism. In combination with the presently available function annotations, we explore potential relationships between different classification categories, and generalize and compare biological features of different lncRNAs within each category. Finally, we present our view on potential further studies. We believe that the classifications of lncRNAs as indicated above are of fundamental importance for lncRNA studies, helpful for further investigation of specific lncRNAs, for formulation of new hypothesis based on different features of lncRNA and for exploration of the underlying lncRNA functional mechanisms.