Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation.

Citation data:

BMC biology, ISSN: 1741-7007, Vol: 14, Issue: 1, Page: 30

Publication Year:
Usage 56
Abstract Views 38
Full Text Views 17
Link-outs 1
Captures 32
Readers 31
Exports-Saves 1
Social Media 498
Shares, Likes & Comments 497
Tweets 1
Citations 3
Citation Indexes 3
Carrió, Elvira; Magli, Alessandro; Muñoz, Mar; Peinado, Miguel A; Perlingeiro, Rita; Suelves, Mònica
Springer Nature
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences
Most Recent Tweet View All Tweets
article description
Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. DNA methylation is an important epigenetic mechanism in the setting and maintenance of cellular identity, but its role in stem cell determination towards the myogenic lineage is unknown. Here we addressed the DNA methylation dynamics of the major genes orchestrating the myogenic determination and differentiation programs in embryonic stem (ES) cells, their Pax7-induced myogenic derivatives, and muscle stem cells in proliferating and differentiating conditions.