High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities.

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PloS one, ISSN: 1932-6203, Vol: 8, Issue: 2, Page: e56506

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10.1371/journal.pone.0056506; 10.1371/journal.pone.0056506.g001; 10.1371/journal.pone.0056506.g007; 10.1371/journal.pone.0056506.g004; 10.1371/journal.pone.0056506.g002; 10.1371/journal.pone.0056506.g006; 10.1371/journal.pone.0056506.g003; 10.1371/journal.pone.0056506.g008; 10.1371/journal.pone.0056506.g005
Pitt D-Scholarship Id:
PMC3577892; 3577892
Alyssa J. Reiffel; Concepcion Kafka; Karina A. Hernandez; Samantha Popa; Justin L. Perez; Sherry Zhou; Satadru Pramanik; Bryan N. Brown; Won Seuk Ryu; Lawrence J. Bonassar; Jason A. Spector; Xiaoming He Show More Hide
Public Library of Science (PLoS); Figshare
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Biotechnology; modulus; hydraulic; permeability; tissue-engineered; bovine; auricular; surgery; biotechnology; pediatrics and child health; width; staining; specimens; harvested; specimen; 1-month; 3-month; samples; safranin; verhoeff; via:twitter
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Autologous techniques for the reconstruction of pediatric microtia often result in suboptimal aesthetic outcomes and morbidity at the costal cartilage donor site. We therefore sought to combine digital photogrammetry with CAD/CAM techniques to develop collagen type I hydrogel scaffolds and their respective molds that would precisely mimic the normal anatomy of the patient-specific external ear as well as recapitulate the complex biomechanical properties of native auricular elastic cartilage while avoiding the morbidity of traditional autologous reconstructions.