The non-enzymatic replication of RNA is thought to have been a critical process required for the origin of life. One unsolved difficulty with non-enzymatic RNA replication is that template-directed copying of RNA results in a double-stranded product. After strand separation, rapid strand reannealing outcompetes slow non-enzymatic template copying, which renders multiple rounds of RNA replication impossible. Here we show that oligoarginine peptides slow the annealing of complementary oligoribonucleotides by up to several thousand-fold; however, short primers and activated monomers can still bind to template strands, and template-directed primer extension can still occur, all within a phase-separated condensed state, or coacervate. Furthermore, we show that within this phase, partial template copying occurs even in the presence of full-length complementary strands. This method to enable further rounds of replication suggests one mechanism by which short non-coded peptides could have enhanced early cellular fitness, and potentially explains how longer coded peptides, that is, proteins, came to prominence in modern biology.
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Retirada de circulação de artigo proeminentevindica Stephen Meyer e o Signature in the Cell David Klinghoffer | @d_klinghoffer 8 de dezembro de 2017, 2:57 PM Ann Gauger acertou na mosca ontem com a notícia de uma grande retirada de circulação de um artigo de 2016 de Jack Szost...
A Nobel Laureate has retracted a 2016 paper in Nature Chemistry that explored the origins of life on earth, after discovering the main conclusions were not correct. Some researchers who study the origins of life on Earth have hypothesized that RNA evolved before DNA or prote...