Desensitization protocol enabling pediatric crossmatch-positive renal transplantation: successful HLA-antibody-incompatible renal transplantation of two highly sensitized children.

Citation data:

Pediatric nephrology (Berlin, Germany), ISSN: 1432-198X, Vol: 32, Issue: 2, Page: 359-364

Publication Year:
2017
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PMID:
27585679
DOI:
10.1007/s00467-016-3489-z
Author(s):
Adamusiak, Anna M; Stojanovic, Jelena; Shaw, Olivia; Vaughan, Robert; Sebire, Neil J; Drage, Martin; Kessaris, Nicos; Marks, Stephen D; Mamode, Nizam
Publisher(s):
Springer Nature
Tags:
Medicine
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article description
Renal transplantation improves quality of life (QoL) and survival in children requiring renal replacement therapy (RRT). Sensitization with development of a broad-spectrum of anti-HLA antibodies as a result of previous transplantation or after receiving blood products is an increasing problem. There are no published reports of desensitization protocols in children allowing renal transplantation from HLA-antibody-incompatible living donors.