High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities.

Citation data:

PloS one, ISSN: 1932-6203, Vol: 8, Issue: 2, Page: e56506

Publication Year:
Usage 30377
Full Text Views 29732
Downloads 351
Abstract Views 184
Clicks 77
Views 30
Link-outs 3
Captures 157
Readers 139
Exports-Saves 17
Bookmarks 1
Social Media 211
Shares, Likes & Comments 197
Tweets 14
Citations 79
Citation Indexes 79
Repository URL:
10.1371/journal.pone.0056506; 10.1371/journal.pone.0056506.g001; 10.1371/journal.pone.0056506.g007; 10.1371/journal.pone.0056506.g004; 10.1371/journal.pone.0056506.g002; 10.1371/journal.pone.0056506.g006; 10.1371/journal.pone.0056506.g003; 10.1371/journal.pone.0056506.g008; 10.1371/journal.pone.0056506.g005
Pitt D-Scholarship Id:
PMC3577892; 3577892
Alyssa J. Reiffel; Concepcion Kafka; Karina A. Hernandez; Samantha Popa; Justin L. Perez; Sherry Zhou; Satadru Pramanik; Bryan N. Brown; Won Seuk Ryu; Lawrence J. Bonassar; Jason A. Spector; Xiaoming He Show More Hide
Public Library of Science (PLoS); Figshare
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Biotechnology; modulus; hydraulic; permeability; tissue-engineered; bovine; auricular; surgery; biotechnology; pediatrics and child health; width; staining; specimens; harvested; specimen; 1-month; 3-month; samples; safranin; verhoeff; via:twitter
Most Recent Tweet View All Tweets
article media
article description
Autologous techniques for the reconstruction of pediatric microtia often result in suboptimal aesthetic outcomes and morbidity at the costal cartilage donor site. We therefore sought to combine digital photogrammetry with CAD/CAM techniques to develop collagen type I hydrogel scaffolds and their respective molds that would precisely mimic the normal anatomy of the patient-specific external ear as well as recapitulate the complex biomechanical properties of native auricular elastic cartilage while avoiding the morbidity of traditional autologous reconstructions.