Collaboration between primitive cell membranes and soluble catalysts.

Citation data:

Nature communications, ISSN: 2041-1723, Vol: 7, Page: 11041

Publication Year:
2016
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PMID:
26996603
DOI:
10.1038/ncomms11041
PMCID:
PMC4802160
Author(s):
Adamala, Katarzyna P; Engelhart, Aaron E; Szostak, Jack W
Publisher(s):
Springer Nature; Nature Research
Tags:
Chemistry; Biochemistry, Genetics and Molecular Biology; Physics and Astronomy
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article description
One widely held model of early life suggests primitive cells consisted of simple RNA-based catalysts within lipid compartments. One possible selective advantage conferred by an encapsulated catalyst is stabilization of the compartment, resulting from catalyst-promoted synthesis of key membrane components. Here we show model protocell vesicles containing an encapsulated enzyme that promotes the synthesis of simple fatty acid derivatives become stabilized to Mg(2+), which is required for ribozyme activity and RNA synthesis. Thus, protocells capable of such catalytic transformations would have enjoyed a selective advantage over other protocells in high Mg(2+) environments. The synthetic transformation requires both the catalyst and vesicles that solubilize the water-insoluble precursor lipid. We suggest that similar modified lipids could have played a key role in early life, and that primitive lipid membranes and encapsulated catalysts, such as ribozymes, may have acted in conjunction with each other, enabling otherwise-impossible chemical transformations within primordial cells.