16S rRNA gene sequencing reveals site-specific signatures of the upper and lower airways of cystic fibrosis patients.
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Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, ISSN: 1873-5010
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Metastasis of upper airway microbiota may have significant implications in the development of chronic lung disease. Here, we compare bacterial communities of matched sinus and lung mucus samples from cystic fibrosis (CF) subjects undergoing endoscopic surgery for treatment of chronic sinusitis.