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Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults.
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JAMA, ISSN: 1538-3598, Vol: 318, Issue: 12, Page: 1150-1160
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Biotinylated antibodies and analogues, with their strong binding to streptavidin, are used in many clinical laboratory tests. Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults.