Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults.

Citation data:

JAMA, ISSN: 1538-3598, Vol: 318, Issue: 12, Page: 1150-1160

Publication Year:
2017
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PMID:
28973622
DOI:
10.1001/jama.2017.13705
ClinicalTrials.gov Identifier:
NCT03034707
Author(s):
Li, Danni; Radulescu, Angela; Shrestha, Rupendra T; Root, Matthew; Karger, Amy B; Killeen, Anthony A; Hodges, James S; Fan, Shu-Ling; Ferguson, Angela; Garg, Uttam; Sokoll, Lori J; Burmeister, Lynn A Show More Hide
Publisher(s):
American Medical Association (AMA)
Tags:
Medicine
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article description
Biotinylated antibodies and analogues, with their strong binding to streptavidin, are used in many clinical laboratory tests. Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults.