Successful bone marrow transplantation in children with severe aplastic anemia using HLA‐partially matched family donors
American Journal of Hematology, ISSN: 1096-8652, Vol: 42, Issue: 3, Page: 328-333
1993
- 11Citations
- 8Captures
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Metrics Details
- Citations11
- Citation Indexes8
- CrossRef6
- Policy Citations3
- Policy Citation3
- Captures8
- Readers8
Article Description
Bone marrow transplantation (BMT) using HLA‐partially matched family donors has produced disappointing results (25–30% of long‐term survivors) in patients with severe aplastic anemia. We describe two children affected by severe aplastic anemia, not responsive to immunosuppressive therapy, who underwent allogeneic bone marrow transplantation using a HLA‐partially matched family donor. Both cases presented 2 first class HLA‐antigens (A and B) disparity between donor and recipient. The pretransplant conditioning regimen consisted of cyclophosphamide, thoracoabdominal irradiation, cytosine‐arabinoside, and antilymphocyte globulin. As graft versus host disease (GVHD) prophylaxis, Cyclosporine‐A was administered at usual dosages for 6 months. A full marrow engraftment was observed in both cases. Only grade I acute GVHD, promptly responsive to corticosteroid therapy, developed with no chronic GVHD. Five months after transplant, both children progressively developed hypertension, renal function impairment, thrombocytopenia, and severe normochromic anemia, with erythropoietin serum levels lower than expected for the haematocrit. After antihypertension treatment and supportive therapy, the clinical picture progressively improved, while treatment with recombinant human erythropoietin completely corrected the long‐lasting anemia. The two children are alive and well 28 months after the transplant, with a Karnofsky score of 100% and a normal peripheral blood count. The authors suggest that, once immunosuppressive therapy has failed, BMT from donors other than HLA‐identical sibling is a feasible approach in children affected by severe aplastic anemia, not having an HLA‐identical donor. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027512616&origin=inward; http://dx.doi.org/10.1002/ajh.2830420315; http://www.ncbi.nlm.nih.gov/pubmed/8438907; https://onlinelibrary.wiley.com/doi/10.1002/ajh.2830420315; https://dx.doi.org/10.1002/ajh.2830420315; https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.2830420315
Wiley
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