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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography

Angewandte Chemie - International Edition, ISSN: 1521-3773, Vol: 56, Issue: 30, Page: 8742-8745
2017
  • 33
    Citations
  • 0
    Usage
  • 63
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    33
  • Captures
    63
  • Mentions
    1
    • Blog Mentions
      1
      • Blog
        1

Article Description

Continuous-flow multistep synthesis is combined with quasi-continuous final-product purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine followed by a heterogeneous catalytic hydrogenation, the desired monosubstituted product can be continuously separated from the co- and by-products in a purity of over 99 % by coupling a flow reactor sequence to a multiple dual-mode (MDM) centrifugal partition chromatography (CPC) device. This purification technique has many advantages over HPLC, such as higher resolution and no need for column replacement or silica recycling, and it does not suffer from irreversible adsorption.

Bibliographic Details

Örkényi, Róbert; Éles, János; Faigl, Ferenc; Vincze, Péter; Prechl, Anita; Szakács, Zoltán; Kóti, János; Greiner, István

Wiley

Chemical Engineering; Chemistry

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