Effects of Polyacrylic Polymers on the Lumenal Proteolysis of Peptide Drugs in the Colon
Journal of Pharmaceutical Sciences, ISSN: 0022-3549, Vol: 84, Issue: 11, Page: 1291-1294
1995
- 58Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations58
- Citation Indexes58
- 58
- CrossRef39
- Captures4
- Readers4
Article Description
□ The in-vitro effectiveness of polyacrylic acid polymers in inhibiting degradation of insulin, calcitonin, and insulin-like growth factor-l by colonic lumenal contents was determined. Further, the effect of Carbopol 974P, a polyacrylic acid polymer, on colonic absorption of insulin in rats was studied. The results revealed that Carbopol 934P, 971P, and 974P all strongly inhibited microbial proteolytic activities against insulin, calcitonin, and insulin-like growth factor-l. Inhibition by Carbopol polymers was complete or almost complete when the concentration of each polymer in saline or in 50 or 100 mM Tris buffer was 0.4%, where the pH of the medium was lower than 5. The extensive inhibition by these polyacrylic acid polymers seems to correlate with their ability to acidify the incubation medium. Further, in-situ absorption studies showed that Carbopol 974P increased the pharmacological availability of colonic insulin. In summary, Carbopol polymers are useful in minimizing colonic proteolysis of peptide drugs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S002235491549937X; http://dx.doi.org/10.1002/jps.2600841107; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028820233&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8587045; https://linkinghub.elsevier.com/retrieve/pii/S002235491549937X; https://dx.doi.org/10.1002/jps.2600841107
Elsevier BV
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