Percent true calcium absorption, mineral metabolism, and bone mineralization in children with cystic fibrosis: Effect of supplementation with vitamin D and calcium
Pediatric Pulmonology, ISSN: 8755-6863, Vol: 43, Issue: 8, Page: 772-780
2008
- 48Citations
- 59Captures
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- Citations48
- Citation Indexes45
- 45
- CrossRef35
- Policy Citations2
- 2
- Clinical Citations1
- PubMed Guidelines1
- Captures59
- Readers59
- 59
Article Description
Objective: To assess whether percent true calcium absorption (α) is normal in children with cystic fibrosis (CF) and to assess whether supplementation with 2,000 IU vitamin D, 1 g calcium, or both will alter α, mineral metabolism, and/or bone mass in children with CF. Study Design: Fifteen children ages 7-13 were randomly assigned to one of four different orders to receive all four 6-month treatments including placebos. Change in 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25(OH) D), PTH, bone turnover markers, and minerals after 6 months, and bone mineral content (Hologic 1000W) after 9 months was measured. α was measured by a dual stable isotope method using Ca intravenously and Ca orally and measuring Ca, Ca, and Ca in a 24-hr urine using High Resolution Inductively Coupled Mass Spectroscopy (HR-ICP-MS). Analysis used Wilcoxon Sign Ranks. Results: α was in the normal range and did not differ by treatment (P 35 ± 10%, Ca 38 ± 23%, D 36 ± 11%, D + Ca 46 ± 21%). One gram calcium did not increase serum or urine calcium. Two thousand IU D did not increase 25-OHD or change 1,25(OH)D. Serum and urine minerals, markers of bone turnover and bone mineral gains did not differ by treatment. Conclusions: α is normal in children with CF. One gram calcium and/or 2,000 IU D does not change α or increase 25-OHD, serum calcium, or mineralization. Longer trials of a significantly higher dose of vitamin D shown to increase serum 25-OHD are needed to assess effects on mineral metabolism and bone mass accrual. However, study of therapeutic options other than calcium and vitamin D should be encouraged. © 2008 Wiley-Liss, Inc.
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