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Antiinflammatory activity of coumarins from Ligusticum lucidum Mill. subsp. cuneifolium (Guss.) Tammaro (Apiaceae)

Phytotherapy Research, ISSN: 0951-418X, Vol: 24, Issue: 11, Page: 1697-1699
2010
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Article Description

Four coumarin derivatives [selidinin 1, (+)-praeruptorin A 2, visnadin 3 and (R)-(+)-7-(2',3'-epoxy-3'-methylbutoxy)-coumarin 4] were isolated from the aerial parts of Ligusticum lucidum Mill. subsp. cuneifolium (Guss.) Tammaro (Apiaceae). This is the first report on the identification of these compounds in the Ligusticum genus. Their topical antiinflammatory activity was evaluated as the inhibition of croton oil-induced ear dermatitis in mice. Each compound (0.3 μmol/cm) induced a significant oedema reduction and compound 4 exerted an effect similar to that of the equimolar dose of the reference drug indomethacin. © 2010 John Wiley & Sons, Ltd.

Bibliographic Details

Menghini, Luigi; Epifano, Francesco; Genovese, Salvatore; Marcotullio, Maria C; Sosa, Silvio; Tubaro, Aurelia

Wiley

Pharmacology, Toxicology and Pharmaceutics

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