In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination.

Citation data:

Stem cells (Dayton, Ohio), ISSN: 1549-4918, Vol: 33, Issue: 11, Page: 3174-80

Publication Year:
2015
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PMID:
26227158
DOI:
10.1002/stem.2115
PMCID:
PMC4762024
Author(s):
Smith, Michelle J., Webber, Beau R., Mohtashami, Mahmood, Stefanski, Heather E., Zún˜iga‐Pflücker, Juan Carlos, Blazar, Bruce R.
Publisher(s):
Wiley-Blackwell
Tags:
Biochemistry, Genetics and Molecular Biology
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review description
T lymphocytes are critical mediators of the adaptive immune system and have the capacity to serve as therapeutic agents in the areas of transplant and cancer immunotherapy. While T cells can be isolated and expanded from patients, T cells derived in vitro from both hematopoietic stem/progenitor cells (HSPCs) and human pluripotent stem cells (hPSCs) offer great potential advantages in generating a self-renewing source of T cells that can be readily genetically modified. T-cell differentiation in vivo is a complex process requiring tightly regulated signals; providing the correct signals in vitro to induce T-cell lineage commitment followed by their development into mature, functional, single positive T cells, is similarly complex. In this review, we discuss current methods for the in vitro derivation of T cells from murine and human HSPCs and hPSCs that use feeder-cell and feeder-cell-free systems. Furthermore, we explore their potential for adoption for use in T-cell-based therapies.

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