Expression of G1-Phase Cell Cycle Genes during Hematopoietic Lineage
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 231, Issue: 1, Page: 73-76
1997
- 40Citations
- 15Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations40
- Citation Indexes40
- 40
- CrossRef20
- Captures15
- Readers15
- 15
Article Description
Characterization of proteins that control the passage through the G 1 phase of the cell cycle is of particular interest because virtually all stimuli regulating cell proliferation or differentiation act primarily during this phase. We have analyzed the G 1 phase proteic machinery, including cyclin D types, cyclin-dependent kinases (CDKs) and CDK inhibitors, of cell populations obtained at different stages of hematopoietic cell lineage. In particular, five cellular phenotypes, namely CD34+ cells (which contain stem cells), BFU-E, CFU-E, CFU-GM and peripheral lymphocytes were studied as representatives of distinct differentiation pathways. The results obtained indicated that all the cellular preparations express cyclin D2 and D3, while cyclin D1, which is the major cyclin D occurring in mesenchimal tissues, is not expressed. Moreover, CDK6 (but not CDK4) was detectable in all the populations investigated. Among the CDK inhibitors studied, p18 INK4C and p19 INK4D signals were clearly evidentiable in the various cell types. Interestingly, high levels of p15 INK4B, a putative tumor suppressor protein, were detectable expecially in granulocyte-monocyte precursors. Our results indicate that a specific hematopoietic G 1 phase machinery occurs, which is conserved during the various steps of the different maturation processes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X97959386; http://dx.doi.org/10.1006/bbrc.1997.5938; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031550559&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9070222; https://linkinghub.elsevier.com/retrieve/pii/S0006291X97959386; https://dx.doi.org/10.1006/bbrc.1997.5938
Elsevier BV
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