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Obesity and Metabolic Syndrome

Diabetes and Kidney Disease, Second Edition, Page: 293-304
2022
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Book Chapter Description

Obesity and associated cardiovascular, metabolic, and renal disorders present a major threat to global health as the prevalence of obesity continues to rise. Excessive adiposity alters the glucose and lipid metabolism through crosstalk with other tissues leading to interconnected pathways that involve adipocytokine dysregulation, insulin resistance, systemic inflammation, and oxidative stress, all of which contribute to kidney injury. This chapter highlights the metabolic derangements that lead to kidney disease and associated complications in the setting of obesity and metabolic syndrome and provides a brief overview of body composition assessment tools in chronic kidney disease.

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