Modelling of L-protein from ebola virus and development of its new inhibitor Molecules: An in silico approach
Applications of Biotechnology for Sustainable Development, Page: 203-208
2017
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Book Chapter Description
L-protein is an RNA-dependent RNA polymerase. It creates many new copies of RNA genome. It is one of the potential and promising anti-Ebola drug targets. It is essentially required for the growth, survival and pathogenesis of the Ebola virus. Thus, to find potent anti-Ebola agents, we have modeled three-dimensional structure of L-protein. The modeled was validated through different tools and subsequently energy minimized. Then structure of potential inhibitor molecules was predicted through pharmacophore models which are based on the existing potent inhibitors' binding modes. Molecular dynamics simulation and docking studies were performed. New potent molecule was reported. Further, the stability of protein-drug complex was also executed. This proposed model and docking study would play a vital role to identify potential lead compounds and treatment against L-protein of Ebola virus.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85043429839&origin=inward; http://dx.doi.org/10.1007/978-981-10-5538-6_23; http://link.springer.com/10.1007/978-981-10-5538-6_23; http://link.springer.com/content/pdf/10.1007/978-981-10-5538-6_23; https://dx.doi.org/10.1007/978-981-10-5538-6_23; https://link.springer.com/chapter/10.1007/978-981-10-5538-6_23
Springer Nature
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