PlumX Metrics
Embed PlumX Metrics

Untersuchungen über den Herzstoffwechsel bei Coronarperfusion nach hypothermer Lagerung

Pflügers Archiv für die Gesamte Physiologie des Menschen und der Tiere, ISSN: 0031-6768, Vol: 290, Issue: 1, Page: 38-55
1966
  • 2
    Citations
  • 0
    Usage
  • 0
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2
    • Citation Indexes
      2

Article Description

Isolated dog hearts were hypothermic stored in a Krebs-Ringer-bicarbonate solution at 4°C and then reperfused with 37° C warm blood through the coronary arteries. The influence of the coronary perfusion on the metabolic changes in the myocardium in dependence from the time of its storage were studied. Two groups of perfused hearts were distinguished. The first group of isolated hearts was reperfused without ATP application during the hypothermic storage. To the second group of hearts 20-25 min after the beginning of the storage ca. 0.5 μMol/g wet weight ATP were injected into the coronary arteries. In all cases of storage from 3 to 8 hours the 40 min-reperfusion resulted in rhythmic heart action. From the obtained results on the metabolic state of reperfused hearts was concluded that the hypothermic hearts reperfused after a storage period no longer than 180 min kept their metabolic state or were able to improve it towards aerobiosis. After ATP addition during storage the ATP, σ ATP, ADP, AMP, phosphocreatine and glycogen in tissue increased. This indicates a direct influence of the external ATP on the hypoxic metabolism of the myocardial cells during hypothermia. A reperfusion of these hearts brought a further improvement of the hypoxic metabolism. © 1966 Springer-Verlag.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know