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Experimente zur Lokalisation der hypothalamischen Steuerung der ACTH-Sekretion

Acta Neurovegetativa, ISSN: 0300-9564, Vol: 23, Issue: 1-2, Page: 35-49
1961
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  • Citations
    8
    • Citation Indexes
      8

Article Description

After bilateral destruction of the ventromedial and dorsomedial hypothalamic nuclei of the guinea-pig the hemorrhagic necrosis of the suprarenal cortex, developing after diphtheria toxin, stays away in the same way as after hypophysectomy. As the development of the hemorrhagic necrosis depends on the simultaneous stimulation of the cortical tissue by ACTH, it may be concluded that the functional elimination of these nuclear areas renders the hypophysic incapable of sufficiently responding to the poisoning with toxin by an increased formation of ACTH. The secretion of 17-OH-corticoid, increased in the normal animal after poisoning with diphtheria toxin, does not increase after functional elimination of the ventromedial and dorsomedial hypothalamic nuclei and succeeding poisoning with toxin; on the contrary, it shows even a distinct tendency to decrease below normal values. The volume of the cellular nuclei of the fasciculate zone of the suprarenal cortex which depends on the degree of ACTH-stimulation increases after poisoning with diphtheria toxin. This increase fails to occur after destruction of the ventromedial and dorsomedial hypothalamic nuclei. It occurs, however, when other hypothalamic areas, e. g., the supraoptic and paraventricular nuclei as well as the socalled median eminence, are destroyed. In animals surviving the destruction of the ventromedial and dorsomedial hypothalamic nuclei for four weeks or more the nuclear volume falls below normal values. Thus, three different criteria for judging the ACTH-output show conformably that the areas of the ventromedial and dorsomedial hypothalamic nuclei play an important part in directing the ACTH-secretion of the adenohypophysis. A non-specific impairment of the corticotrope activity in localizing the seats of coagulation in these nuclear areas is little probable, for there is a relatively wide belt of intact hypothalamic tissue between the seats of injury and the place where the hypophyseal stalk originates. Besides, according to the test methods used, the functional elimination of the median eminence results in an essentially lesser impairment of the ACTH-secretion than the destruction of the above-mentioned nuclear areas, with the median eminence remaining intact. © 1961 Springer-Verlag.

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