Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects
Inflammation, ISSN: 0360-3997, Vol: 20, Issue: 6, Page: 673-681
1996
- 61Citations
- 28Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations61
- Citation Indexes61
- 61
- CrossRef43
- Captures28
- Readers28
- 28
Article Description
Objective. To evaluate neutrophil functions in the elderly. Methods. We investigated the PMN migration in vivo and PMN superoxide production and adhesion in response to a variety of compounds; PMN have been isolated both from blood and from a skin experimental exudate (obtained by Senn's skin window technique) of 25 normal elderly and of 25 normal young control subjects. Results. No difference was found in PMN migration in vivo (62.9 ± 21.3 x 10 and 65.5 ± 9.1 x 10 PMN/cm /24 hours in elderly and young subjects respectively), neither were different the adhesion under basal condition and after some stimuli and the superoxide production in basal condition and in response to STZ and PMA in two groups. In elderly subjects superoxide production, in response to fMLP, markedly resulted lower than in young controls both by circulating PMNs (3.6 ± 2.7 and 9.3 ± 3.3 nMOLES 0 /10 PMN respectively, p < 0.0001) and by exudate PMNs (13.6 ± 4.3 and 19.4 ± 6 nMOLES 0 /10 PMNs respectively, p < 0.005). Conclusion. Many PMN functions in the elderly do not differ from young people, suggesting that the overall defense function of these cells is not affected by aging. The only parameter that we have found to be different between the two groups is the poor superoxide production after fMLP stimulus of PMNs. The stimulus- and function-specificity of this defect in PMNs from elderly subjects indicates the existence of a dysregulation of the signal transduction pathway distal to fMLP receptor and proximal to NADPH oxidase activation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030446825&origin=inward; http://dx.doi.org/10.1007/bf01488803; http://www.ncbi.nlm.nih.gov/pubmed/8979154; http://link.springer.com/10.1007/BF01488803; http://www.springerlink.com/index/pdf/10.1007/BF01488803; https://dx.doi.org/10.1007/bf01488803; https://link.springer.com/article/10.1007/BF01488803; http://www.springerlink.com/index/10.1007/BF01488803
Springer Nature
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know