Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer
Diseases of the Colon and Rectum, ISSN: 0012-3706, Vol: 41, Issue: 3, Page: 310-315
1998
- 85Citations
- 18Captures
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- Citations85
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- 84
- CrossRef58
- Patent Family Citations1
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- Captures18
- Readers18
- 18
Article Description
INTRODUCTION: Guanylyl cyclase C appears to be expressed only in colorectal cancer cells in extraintestinal tissues. Thus, guanylyl cyclase C may be useful as a marker to detect colorectal cancer micrometastases not detectable by histopathology in lymph nodes of patients. METHODS: Twelve patients with colon adenocarcinoma, Dukes Stages A through C2, and one patient with a tubulovillous adenoma were included in this study. Forty-two lymph nodes were collected from fresh surgical specimens, and each was examined by histopathology and reverse transcription followed by polymerase chain reaction using guanylyl cyclase C-specific primers. Histopathology identified colon cancer cells in 6 of 16 lymph nodes from five Dukes Stage C patients but not in lymph nodes from the patient with a tubulovillous adenoma, the Dukes Stage A patient, or six Dukes Stage B patients. Reverse transcription followed by polymerase chain reaction using guanylyl cyclase C- specific primers was performed on all 42 lymph nodes. RESULTS: Guanylyl cyclase C messenger RNA was not detected by reverse transcription followed by polymerase chain reaction in lymph nodes from the patient with the tubulovillous adenoma or the patient with Dukes Stage A colon carcinoma. Seven lymph nodes from Dukes Stage C patients revealed guanylyl cyclase C messenger RNA including six lymph nodes containing histopathologically confirmed metastases. Of significance, guanylyl cyclase C messenger RNA was detected in 6 of 21 lymph nodes from Dukes Stage B patients. Indeed, clinical staging of two patients could be upgraded from B to C using reverse transcription followed by polymerase chain reaction and guanylyl cyclase C- specific primers. CONCLUSION: Reverse transcription followed by polymerase chain reaction using guanylyl cyclase C-specific primers might be useful to more accurately assess micrometastases in lymph nodes of colorectal cancer patients undergoing disease staging.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031938629&origin=inward; http://dx.doi.org/10.1007/bf02237484; http://www.ncbi.nlm.nih.gov/pubmed/9514425; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00003453-199841030-00006; http://www.springerlink.com/index/pdf/10.1007/BF02237484; https://journals.lww.com/00003453-199841030-00006; https://dx.doi.org/10.1007/bf02237484; https://journals.lww.com/dcrjournal/Abstract/1998/41030/Use_of_guanylyl_cyclase_c_for_detecting.6.aspx; http://www.springerlink.com/index/10.1007/BF02237484
Ovid Technologies (Wolters Kluwer Health)
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