Evidence for a megareplicon covering megabases of centromeric chromosome segments
Chromosome Research, ISSN: 0967-3849, Vol: 4, Issue: 3, Page: 240-247
1996
- 31Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations31
- Citation Indexes31
- 31
- CrossRef22
- Captures12
- Readers12
- 12
Article Description
We have analysed the replication of the heterochromatic megachromosome that was formed de novo by a large scale amplification process initiated in the centromeric region of mouse chromosome 7. The megachromosome is organized into amplicons ~30 Mb in size, and each amplicon consists of two large inverted repeats delimited by a primary replication initiation site. Our results suggest that these segments represent a higher order replication unit (megareplicon) of the centromeric region of mouse chromosomes. Analysis of the replication of the megareplicons indicates that the pericentric. heterochromatin and the centromere of mouse chromosomes begin to replicate early, and that their replication continues through approximately three-quarters of the S-phase. We suggest that a replication-directed mechanism may account for the initiation of large-scale amplification in the centromeric regions of mouse chromosomes, and may also explain the formation of new, stable chromosome segments and chromosomes.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=8944238472&origin=inward; http://dx.doi.org/10.1007/bf02254965; http://www.ncbi.nlm.nih.gov/pubmed/8793209; http://link.springer.com/10.1007/BF02254965; http://www.springerlink.com/index/pdf/10.1007/BF02254965; https://dx.doi.org/10.1007/bf02254965; https://link.springer.com/article/10.1007/BF02254965; http://www.springerlink.com/index/10.1007/BF02254965
Springer Nature
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