Autoradiographic analysis of hormone-independent development of the mouse vaginal epithelium in organ culture
In Vitro, ISSN: 0073-5655, Vol: 10, Issue: 1-2, Page: 42-50
1974
- 7Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations7
- Citation Indexes7
- CrossRef6
- Captures1
- Readers1
Article Description
Epithelial development was studied in organ cultures of vaginas from ovariectomized mice. In defined medium without estrogen, basal cell proliferation and formation of a stratified squamous epithelium occurred spontaneously in a high percentage of cases. During this "spontaneous" development, the length of the cell cycle and duration of DNA synthesis were the same as those occurring in vivo in response to estrogen. RNA synthesis was also stimulated. Thus, spontaneous development in vitro appears to resemble estrogen-induced development in vivo both qualitatively and quantitatively. In vitro, estrogen was found to have no detectable effect on the atrophic epithelium. In addition, estrogen was unable to halt degeneration of the fully developed epithelium on explants that had been estrogen-primed in vivo. The results suggest that both hormone-dependence and ability of hormones to induce a response are dependent on cell environmental factors. © 1974 Tissue Culture Association.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0016082905&origin=inward; http://dx.doi.org/10.1007/bf02615337; http://www.ncbi.nlm.nih.gov/pubmed/4478969; http://link.springer.com/10.1007/BF02615337; http://www.springerlink.com/index/pdf/10.1007/BF02615337; http://www.springerlink.com/index/10.1007/BF02615337; https://dx.doi.org/10.1007/bf02615337; https://link.springer.com/article/10.1007/BF02615337
Springer Nature
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