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The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism

Biological Trace Element Research, ISSN: 0163-4984, Vol: 33, Issue: 1-3, Page: 37-42
1992
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Selenium deficiency impairs thyroid hormone metabolism by inhibiting the synthesis and activity of the iodothyronine deiodinases, which convert thyroxine (T) to the more metabolically active 3,3′-5 triiodothyronine (T). Hepatic type I iodothyronine deiodinase, identified in partially purified cell fractions using affinity labeling with [I]N-bromoacetyl reverse triiodothyronine, is also labeled withSe by in vivo treatment of rats withSe-NaSeO. Thus, the type I iodothyronine 5′-deiodinase is a selenoenzyme. In rats, concurrent selenium and iodine deficiency produces greater increases in thyroid weight and plasma thyrotrophin than iodine deficiency alone. These results indicate that a concurrent selenium deficiency could be a major determinant of the severity of iodine deficiency. © 1992 Humana Press Inc.

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