The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism
Biological Trace Element Research, ISSN: 0163-4984, Vol: 33, Issue: 1-3, Page: 37-42
1992
- 50Citations
- 31Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations50
- Citation Indexes48
- 48
- CrossRef34
- Policy Citations2
- Policy Citation2
- Captures31
- Readers31
- 31
Article Description
Selenium deficiency impairs thyroid hormone metabolism by inhibiting the synthesis and activity of the iodothyronine deiodinases, which convert thyroxine (T) to the more metabolically active 3,3′-5 triiodothyronine (T). Hepatic type I iodothyronine deiodinase, identified in partially purified cell fractions using affinity labeling with [I]N-bromoacetyl reverse triiodothyronine, is also labeled withSe by in vivo treatment of rats withSe-NaSeO. Thus, the type I iodothyronine 5′-deiodinase is a selenoenzyme. In rats, concurrent selenium and iodine deficiency produces greater increases in thyroid weight and plasma thyrotrophin than iodine deficiency alone. These results indicate that a concurrent selenium deficiency could be a major determinant of the severity of iodine deficiency. © 1992 Humana Press Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026632720&origin=inward; http://dx.doi.org/10.1007/bf02783990; http://www.ncbi.nlm.nih.gov/pubmed/1379458; http://link.springer.com/10.1007/BF02783990; http://www.springerlink.com/index/pdf/10.1007/BF02783990; http://www.springerlink.com/index/10.1007/BF02783990; https://dx.doi.org/10.1007/bf02783990; https://link.springer.com/article/10.1007/BF02783990
Springer Nature
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