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Pseudofollicular nests of plasmacells (of a special type?) in paracortical pulp of human lymph nodes

Virchows Archiv B Cell Pathology Zell-pathologie, ISSN: 0042-6431, Vol: 14, Issue: 1, Page: 47-56
1973
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A comparative light and electron microscopic study of the so-called Lymphoblastennester (nests of lymphoblasts) (Lennert) in 5 lymph node biopsies was performed. Light microscopically these cells are characterized by a uniform, lightly stained, oval nucleus with a small, but prominent nucleolus. The weakly basophilic cytoplasm is moderately large, well defined and strains grey-blue with Giemsa. These cells are arranged in small or larger groups showing a topographic relation to the postcapillary venules and the intermediary sinuses of the paracortical pulp of the lymph nodes. Electron microscopically the dominating cell type of these "nests" shows a well developed ergastoplasm and a prominent Golgi-apparatus. The ergastoplasm is composed of long, rough-surfaced tubules lying parallel to the nucleus, and of small vesicles. The lightly stained cytoplasm contains only few ribosomes or polysomes. These cells represent a morphologically separate type of plasma cells. Their origin and functional significance, however, remains uncertain. © 1973 Springer-Verlag.

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